Continuously updated synthesis method about 31181-89-2

Here is just a brief introduction to this compound(31181-89-2)Electric Literature of C6H4ClNO, more information about the compound(5-Chloropicolinaldehyde) is in the article, you can click the link below.

Electric Literature of C6H4ClNO. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Nonacidic Farnesoid X Receptor Modulators. Author is Flesch, Daniel; Cheung, Sun-Yee; Schmidt, Jurema; Gabler, Matthias; Heitel, Pascal; Kramer, Jan; Kaiser, Astrid; Hartmann, Markus; Lindner, Mara; Lueddens-Daemgen, Kerstin; Heering, Jan; Lamers, Christina; Lueddens, Hartmut; Wurglics, Mario; Proschak, Ewgenij; Schubert-Zsilavecz, Manfred; Merk, Daniel.

As a cellular bile acid sensor, farnesoid X receptor (FXR) participates in regulation of bile acid, lipid and glucose homeostasis, and liver protection. Clin. results have validated FXR as therapeutic target in hepatic and metabolic diseases. To date, potent FXR agonists share a neg. ionizable function that might compromise their pharmacokinetic distribution and behavior. Here the authors report the development and characterization of a high-affinity FXR modulator not comprising an acidic residue.

Here is just a brief introduction to this compound(31181-89-2)Electric Literature of C6H4ClNO, more information about the compound(5-Chloropicolinaldehyde) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate