The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloropicolinaldehyde(SMILESS: O=CC1=NC=C(Cl)C=C1,cas:31181-89-2) is researched.Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane. The article 《Construction of Protoberberine Alkaloid Core through Palladium Carbene Bridging C-H Bond Functionalization and Pyridine Dearomatization》 in relation to this compound, is published in ACS Catalysis. Let’s take a look at the latest research on this compound (cas:31181-89-2).
Compounds, e.g. I with a pyridoisoquinolinone core often appear as members of the protoberberine alkaloid family. Traditional methods to construct this framework normally rely on manipulation of sophisticated reactants. Herein, a palladium-catalyzed reaction of readily available pyridotriazoles and o-bromo/pseudohalo benzaldehydes is described, which provides a modular approach to pyridoisoquinolinone derivatives This methodol. provides a concise synthetic route to prepare protoberberine-type alkaloids. The role of pyridotriazole is 2-fold, acting as a relay reagent to promote C-H bond functionalization and undergoing pyridine dearomatization to construct the polycyclic system.
From this literature《Construction of Protoberberine Alkaloid Core through Palladium Carbene Bridging C-H Bond Functionalization and Pyridine Dearomatization》,we know some information about this compound(31181-89-2)Reference of 5-Chloropicolinaldehyde, but this is not all information, there are many literatures related to this compound(31181-89-2).
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate