Application In Synthesis of trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium, is researched, Molecular C46H46O4P2Pd2, CAS is 172418-32-5, about Radiobromination of closo-carboranes using palladium-catalyzed halogen exchange. Author is Winberg, Karl Johan; Mume, Eskender; Tolmachev, Vladimir; Sjoeberg, Stefan.
Closo-Carborane derivatives are often proposed as boron carriers for use in boron neutron capture therapy (BNCT) of cancer. A positron emitting radiolabel on a boron atom in such carborane compounds might facilitate pharmacokinetic studies in patients. In this paper the four iodo-closo-carboranes, namely 3-iodo-ortho-carborane, 9-iodo-ortho-carborane, 9-iodo-meta-carborane and 2-iodo-para-carborane were chosen as model compounds in a study of [76Br]bromine labeling of carboranes using palladium-catalyzed halogen exchange. It was found that within a reaction time of 40 min, the four compounds were all radio-brominated in good to excellent yield, using Herrmann’s catalyst (HC) in toluene.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate