So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.He, Jun; Xue, Yuhang; Han, Bo; Zhang, Chunzhu; Wang, You; Zhu, Shaolin researched the compound: 1-(Bromomethyl)-2-iodobenzene( cas:40400-13-3 ).Product Details of 40400-13-3.They published the article 《Nickel-Catalyzed Asymmetric Reductive 1,2-Carboamination of Unactivated Alkenes》 about this compound( cas:40400-13-3 ) in Angewandte Chemie, International Edition. Keywords: chiral amine synthesis pyrox nickel catalyzed asym reductive carboamination; pyrox nickel catalyzed reductive carboamination alkene benzoyl hydroxylamine; alkenes; asymmetric catalysis; carboamination; nickel; synthetic methods. We’ll tell you more about this compound (cas:40400-13-3).
Starting from diverse alkene-tethered aryl iodides and O-benzoyl-hydroxylamines, the enantioselective reductive cross-electrophilic 1,2-carboamination of unactivated alkenes was achieved using a chiral pyrox/nickel complex as the catalyst. This mild, modular, and practical protocol provides rapid access to a variety of β-chiral amines with an enantioenriched aryl-substituted quaternary carbon center in good yields and with excellent enantioselectivities. This process reveals a complementary regioselectivity when compared to Pd and Cu catalysis.
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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate