The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 1-bromocyclopropanecarboxylate( cas:89544-83-2 ) is researched.Application In Synthesis of Ethyl 1-bromocyclopropanecarboxylate.Peng, Jianbiao; Hu, Qiyue; Gu, Chunyan; Liu, Bonian; Jin, Fangfang; Yuan, Jijun; Feng, Jun; Zhang, Lei; Lan, Jiong; Dong, Qing; Cao, Guoqing published the article 《Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model》 about this compound( cas:89544-83-2 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: uric acid transporter inhibitor; 3D pharmacophore; Gout; Hyperuricemia; URAT1 homology model; URAT1 inhibitors. Let’s learn more about this compound (cas:89544-83-2).
This Letter describes the discovery of a series of potent inhibitors of Human Uric Acid Transporter 1 (hURAT1). Lead generation and optimization via 3D pharmacophore anal. resulted in compound (I). With an IC50 of 33.7 nM, I also demonstrated good oral bioavailability in rat (74.8%) and displayed a consistent PK profile across all species tested (rat, dog and monkey).
From this literature《Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model》,we know some information about this compound(89544-83-2)Application In Synthesis of Ethyl 1-bromocyclopropanecarboxylate, but this is not all information, there are many literatures related to this compound(89544-83-2).
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate