Alsanosy, Rashad; Alhazmi, Hassan A.; Sultana, Shahnaz; Abdalla, Ashraf N.; Ibrahim, Yassin; Al Bratty, Mohammed; Banji, David; Khardali, Ibrahim; Khalid, Asaad published an article about the compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol( cas:1824-94-8,SMILESS:O[C@H]([C@H]([C@H]([C@@H](CO)O1)O)O)[C@@H]1OC ).Recommanded Product: 1824-94-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1824-94-8) through the article.
The khat plant has been culturally used in many parts of Africa and the Arabian Peninsula for many years to induce psychostimulating effect. Because of the global wide-spreading nature, khat chewing is being considered as a universally growing problem. Catha abbottii, Catha edulis, and Catha transvaalensis are the three species of khat commonly chewed in Saudi Arabia and nearby regions. Khat users usually prefer to chew young leaves over mature ones due to the diverse effects produced by both. Though many of the constituents of khat leaves have been identified, the complete phytochem. profile of young and mature leaves was not performed or compared; also, no evidence is available to affirm the cytotoxicity of young or mature leaves. Therefore, this study aimed to investigate the phytochem. basis of the differential response of the young and mature leaves and to assess the cytotoxicity of young and mature khat leaves. Ethanolic extracts of young and mature leaves of three khat cultivars were subjected to GC-MS. Hierarchical cluster anal. revealed the existence of two major clusters. The extracts of young leaves were found to contain the maximum content of cathinone; however, methoxyamphetamine was found in only one extract of young leaves. Cytotoxicity investigations were also conducted on both types of leaves using three cancer cell lines, human breast adenocarcinoma, human ovary adenocarcinoma, and human colon adenocarcinoma and also normal human fetal lung fibroblast cell line was used. All extracts showed comparable cytotoxicity, IC50 ranging from 22-59 μg/mL on the cancer cells; however, we observed more cytotoxicity against normal cells (IC50: 6-41 μg/mL). The predominant cytotoxicity on normal cells may pose many health hazards to khat consumers.
As far as I know, this compound(1824-94-8)Recommanded Product: 1824-94-8 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate