Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, ACS Catalysis called Enantioselective Access to γ-All-Carbon Quaternary Center-Containing Cyclohexanones by Palladium-Catalyzed Desymmetrization, Author is Wei, Qiang; Cai, Jinhui; Hu, Xu-Dong; Zhao, Jing; Cong, Hengjiang; Zheng, Chao; Liu, Wen-Bo, which mentions a compound: 40400-13-3, SMILESS is BrCC1=C(I)C=CC=C1, Molecular C7H6BrI, Recommanded Product: 1-(Bromomethyl)-2-iodobenzene.
An efficient desymmetrization of γ-quaternary carbon-containing cyclohexanones using readily available Pd/(S)-tBuPhox and benzyl amine as dual catalysts is reported. The development of the reaction, exploration on the substrate scope, and studies on the reaction mechanism. The intramol. coupling reaction leads to the formation of bicyclo[3.3.1]nonanones with a quaternary carbon bridgehead in synthetically useful yields (up to 98%) with high enantioselectivities (up to 98:2 er) and good functional group tolerance (>30 examples). Significantly, aryl and alkenyl bromides, as well as less reactive triflates are all compatible substrates for this process. The synthetic versatility of this strategy is demonstrated by scale-up synthesis and diverse transformations of the products into valuable building blocks, including quaternary center-containing dihydronaphthalenes, ring-fused indole and lactone, tetralones, and 6,6,5-tricycles. Mechanistic studies by computational calculations provide insights into the role of benzyl amine in accelerating the reaction rate and enhancing the enantioselectivities.
As far as I know, this compound(40400-13-3)Recommanded Product: 1-(Bromomethyl)-2-iodobenzene can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate