HPLC of Formula: 49609-84-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Synthesis and anthelmintic activity of benzopyrano[2,3-c]pyrazol-4(2H)-one derivatives. Author is Milisiunaite, Vaida; Kadlecova, Alena; Zukauskaite, Asta; Dolezal, Karel; Strnad, Miroslav; Voller, Jiri; Arbaciauskiene, Egle; Holzer, Wolfgang; Sackus, Algirdas.
A series of benzopyrano[2,3-c]pyrazol-4(2H)-one derivatives I [R1 = Me, Ph; R2 = H, F; R3 = H, F, Cl, etc.; R4 = H, F] were synthesized from readily available 1-phenyl- and 1-methyl-1H-pyrazol-3-ols by sequentially employing O-acylation, Fries rearrangement and potassium carbonate-induced cyclization. The anthelmintic properties of the obtained compounds were investigated in-vivo in a model nematode, Caenorhabditis elegans. Five compounds, I [R1 = Ph, R2 = R3 = R4 = H; R1 = Ph, R2 = R4 = H, R3 = F; R1 = Ph, R2 = R4 = H, R3 = Cl; R1 = Ph, R2 = R4 = H, R3 = Br; R1 = Ph, R2 = F, R3 = R4 = H] altered the development of C. elegans. While the activities of I [R1 = Ph, R2 = R3 = R4 = H; R1 = Ph, R2 = F, R3 = R4 = H] were rather modest, compounds I [R1 = Ph, R2 = R4 = H, R3 = F; R1 = Ph, R2 = R4 = H, R3 = Cl; R1 = Ph, R2 = R4 = H, R3 = Br] inhibited the growth of the worms at concentrations of approx. 1-3μM. At these concentrations, the compounds did not kill the worms, but they strongly inhibited their development, with the majority of larvae never progressing past the L1 stage. Moreover, testing in non-cancer human cell lines showed that, with exception of 7-bromo derivative I [R1 = Ph, R2 = R4 = H, R3 = Br], the active compounds showed favorable toxicity profiles.
There is still a lot of research devoted to this compound(SMILES：O=C(Cl)C1=CC=CN=C1Cl)HPLC of Formula: 49609-84-9, and with the development of science, more effects of this compound(49609-84-9) can be discovered.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate