So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Pei-Pei; Wang, Qiao; Min, Li-Jing; Wu, Hong-Ke; Weng, Jian-Quan; Tan, Cheng-Xia; Zhang, Yong-Gang; Liu, Xing-Hai researched the compound: 2-Chloronicotinoyl chloride( cas:49609-84-9 ).HPLC of Formula: 49609-84-9.They published the article 《Synthesis, crystal structure, fungicidal activity and molecular docking of nicotinic acyl urea derivatives》 about this compound( cas:49609-84-9 ) in Journal of Molecular Structure. Keywords: nicotinic acyl urea preparation plant fungicide mol docking; structure activity nicotinic acyl urea plant fungicide. We’ll tell you more about this compound (cas:49609-84-9).
A series of nicotinic acyl urea derivatives I (R1 = 4-F, 2-OCF3, 2,3,4-F3, etc.) were designed using boscalid as a lead compound They were synthesized via four steps. Their structures were confirmed by 1H NMR, HRMS and X-ray diffraction. Some of these new nicotinic acyl urea derivatives I [R1 = 2-CF3, 3-F, 2,3,4-F2, 4-[CF(CF3)2]-2-Me] had moderate fungicidal activity against Gibberella zeae, Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea and Physalospora piricola at 50 mg/L, which is a little weaker than the com. fungicide fluxapyroxad. The SAR was studied by using mol. docking.
There is still a lot of research devoted to this compound(SMILES：O=C(Cl)C1=CC=CN=C1Cl)HPLC of Formula: 49609-84-9, and with the development of science, more effects of this compound(49609-84-9) can be discovered.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate