Something interesting about 1824-94-8

There is still a lot of research devoted to this compound(SMILES：O[C@H]([C@H]([C@H]([C@@H](CO)O1)O)O)[C@@H]1OC)COA of Formula: C7H14O6, and with the development of science, more effects of this compound(1824-94-8) can be discovered.

COA of Formula: C7H14O6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol, is researched, Molecular C7H14O6, CAS is 1824-94-8, about Benzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimization. Author is Hassan, Mujtaba; van Klaveren, Sjors; Haakansson, Maria; Diehl, Carl; Kovacic, Rebeka; Baussiere, Floriane; Sundin, Anders P.; Dernovsek, Jaka; Walse, Bjoern; Zetterberg, Fredrik; Leffler, Hakon; Anderluh, Marko; Tomasic, Tihomir; Jakopin, Ziga; Nilsson, Ulf J..

We have obtained the X-ray crystal structure of the galectin-8 N-terminal domain (galectin-8N) with a previously reported quinoline-galactoside ligand at a resolution of 1.6 Å. Based on this X-ray structure, a collection of galactosides derivatized at O3 with triazole, benzimidazole, benzothiazole, and benzoxazole moieties were designed and synthesized. This led to the discovery of a 3-O-(N-methylbenzimidazolylmethyl)-galactoside with a Kd of 1.8μM for galectin-8N, the most potent selective synthetic galectin-8N ligand to date. Mol. dynamics simulations showed that benzimidazole-galactoside derivatives bind the non-conserved amino acid Gln47, accounting for the higher selectivity for galectin-8N. Galectin-8 is a carbohydrate-binding protein that plays a key role in pathol. lymphangiogenesis, modulation of the immune system, and autophagy. Thus, the benzimidazole-derivatized galactosides, e.g. I, represent promising compounds for studies of the pathol. implications of galectin-8, as well as a starting point for the development of antitumor and antiinflammatory therapeutics targeting galectin-8.

There is still a lot of research devoted to this compound(SMILES：O[C@H]([C@H]([C@H]([C@@H](CO)O1)O)O)[C@@H]1OC)COA of Formula: C7H14O6, and with the development of science, more effects of this compound(1824-94-8) can be discovered.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate