HPLC of Formula: 3435-27-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-(tert-Butyl)pyrimidin-4-amine, is researched, Molecular C8H13N3, CAS is 3435-27-6, about Pyrimidines. Part LXX. Investigations into the cine-amination of 4-substituted-5-bromopyrimidines by potassium amide in liquid ammonia. Author is Rasmussen, C. A. H.; Van der Plas, H. C.; Grotenhuis, P.; Koudijs, A..
15N-labeling experiments showed that amination of I [R = Me3C, Ph, MeO, piperidino (II), Me, MeNH, PhNH, NH2] with KNH2/NH3 to give III proceeds in part via an SN(ANRORC) mechanism (involving an open-chain intermediate) if the R group does not contain an acidic proton in the position α to the ring. II gave IV in addition to II (R = piperidino); this tele-amination does not involve an SN(ANRORC) mechanism.
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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate