Safety of 2-Chloronicotinoyl chloride. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about α-Arylation of (hetero)aryl ketones in aqueous surfactant media. Author is Wood, Alex B.; Roa, Daniel E.; Gallou, Fabrice; Lipshutz, Bruce H..
The α-arylation reactions can be performed in water and enabled by a designer surfactant under mild conditions and in the absence of organic co-solvents. Multitude of aryl and heteroaryl ketones such as propiophenone, 6,7-dihydro-4-benzo[b]thiophenone, 1-thiazol-2-yl-propan-1-one, 2-(1-benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one, etc. are amenable to coupling with functionalized aryl halides ArBr (Ar = naphthalen-2-yl, 4-(morpholin-4-yl)benzen-1-yl, pyridin-3-yl, 1-benzyl-1H,2H,3H-pyrrolo[2,3-b]pyridin-5-yl, etc.). Use of a lipophilic base that can gain entry to the micellar inner cores mediates enolization. In some cases, palladium loadings as low as 2500 ppm (0.25 mol%) are sufficient for coupling in a completely recyclable medium, exemplifying chem. in water.
If you want to learn more about this compound(2-Chloronicotinoyl chloride)Safety of 2-Chloronicotinoyl chloride, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(49609-84-9).
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate