The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloronicotinoyl chloride( cas:49609-84-9 ) is researched.Electric Literature of C6H3Cl2NO.Takale, Balaram S.; Thakore, Ruchita R.; Mallarapu, Rushil; Gallou, Fabrice; Lipshutz, Bruce H. published the article 《A sustainable 1-pot, 3-step synthesis of boscalid using ppm level Pd catalysis in water》 about this compound( cas:49609-84-9 ) in Organic Process Research & Development. Keywords: boscalid preparation; reduction Suzuki Miyaura cross coupling acylation. Let’s learn more about this compound (cas:49609-84-9).
Herein is disclosed a 1-pot, 3-step route for the synthesis of boscalid using nanomicelles in water as the reaction medium, and a very low loading (700 ppm or 0.07 mol %) of costly and endangered Pd. The developed sequence involves an initial Suzuki-Miyaura cross-coupling, the product from which is not isolated. The second step relies on a carbonyl iron powder (CIP) reduction of the aryl nitro group, followed by the third and final step involving an acylation with the required chloronicotinyl chloride. The overall isolated yield for these three steps is 83%.
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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate