The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloronicotinoyl chloride(SMILESS: O=C(Cl)C1=CC=CN=C1Cl,cas:49609-84-9) is researched.Synthetic Route of C10H12ClIN2O2. The article 《Synthesis and evaluation of biological properties of 2-(2-(phenoxy)pyridin-3-yl)quinazolin-4(3H)-one derivatives》 in relation to this compound, is published in Heterocycles. Let’s take a look at the latest research on this compound (cas:49609-84-9).
A series of novel title compounds I (R = 3,5-(Me)2, 2-F, 4-I, etc.) was designed and synthesized as antitumor agents. The antitumor activities of target compounds I were evaluated and compared with pos. drug Gefitinib employing standard MTT assay against A549 (human lung adenocarcinoma cell), PC-3 (prostate cancer cells), K562 (human chronic myeloid leukemia cells), HepG2 (human liver cancer cell) cancer cell lines in vitro. The pharmacol. screening results revealed that many compounds exhibited moderate levels of antitumor activities against four cancer cell lines, especially compound I (R = 3,5-(Me)2) displayed promising activities against A549 (IC50 = 12.47±2.86μM) than Gefitinib (IC50 = 17.37±6.01μM). The mechanism and the apoptosis inducing effect of I (R = 3,5-(Me)2) against A549 cell line were studied. The results showed that I (R = 3,5-(Me)2) could inhibit migration and motility of cancer cells, induce cell apoptosis and exhibit the typical apoptotic morphol.
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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate