The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloronicotinoyl chloride( cas:49609-84-9 ) is researched.Safety of 2-Chloronicotinoyl chloride.Beesu, Mallesh; Mehta, Goverdhan published the article 《Synthesis of Quinolines and Isoquinolines via Site-Selective, Domino Benzannulation of 2- and 3-Chloropyridyl Ynones with Nitromethane》 about this compound( cas:49609-84-9 ) in Journal of Organic Chemistry. Keywords: quinoline isoquinoline preparation domino benzannulation chloropyridyl ynone nitromethane. Let’s learn more about this compound (cas:49609-84-9).
An approach of general applicability to diverse quinolines and isoquinolines via a tactic that uses the recursive anion from nitromethane as a 1C-connector to stitch easily and appropriately crafted pyridyl ynones through a transition-metal-free, tandem Michael addition-SNAr process is delineated. The straightforwardness, one-pot operation, and good yields mark this methodol. for wider exploitation in targeting more embellished quinolines and isoquinolines and complex platforms embodying these moieties.
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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate