Related Products of 13991-08-7. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 13991-08-7, Name is 1,2-Bis(diphenylphosphino)benzene
The present invention provides a 2 – aryl cyclopropyl amine compound of preparation method, which belongs to the technical field of organic synthetic chemistry. To solve the problems of low efficiency of the existing preparation ACPA, polysubstituted ACPA problem cannot be obtained. The method includes: in the reaction container by adding organic solvent, then adding copper catalyst and ligand, then adding alkali, then adding borate, finally adding cyclopropene compound and hydroxylamine – O – benzoate reaction, to obtain 2 – aryl cyclopropyl amine compound. The invention route the succinct high-efficient, mild reaction conditions, the preparation method can quickly obtain a large amount of multi-substituted 2 – aryl cyclopropyl amine derivatives, the obtained product 2 – aryl ring amine can be used as the treatment of cancer, diabetes, aids various diseases such as important physiologically active compound, some of the representative compounds in vitro cytotoxicity test shows that, to obtain the compound of many types of cancer cells are obviously inhibit function. (by machine translation)
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Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate