Synthetic Route of 13991-08-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 13991-08-7, C30H24P2. A document type is Article, introducing its new discovery.
While iron-catalyzed C-H activation offers an attractive reaction methodology for organic transformations, the lack of molecular-level insight into the in situ formed and reactive iron species impedes continued reaction development. Herein, freeze-trapped 57Fe Moessbauer spectroscopy and single-crystal X-ray crystallography combined with reactivity studies are employed to define the key cyclometalated iron species active in triazole-assisted iron-catalyzed C-H activation. These studies provide the first direct experimental definition of an activated intermediate, which has been identified as the low-spin iron(II) complex [(sub-A)(dppbz)(THF)Fe]2(mu-MgX2), where sub-A is a deprotonated benzamide substrate. Reaction of this activated intermediate with additional diarylzinc leads to the formation of a cyclometalated iron(II)-aryl species, which upon reaction with oxidant, generates C-H arylated product at a catalytically relevant rate. Furthermore, pseudo-single-turnover reactions between catalytically relevant iron intermediates and excess nucleophile identify transmetalation as rate-determining, whereas C-H activation is shown to be facile under the reaction conditions.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate