Related Products of 1608-26-0. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 1608-26-0, Name is Tris(dimethylamino)phosphine
. In a document type is Article, introducing its new discovery.
Hydrolytic reactions of 2?,3?-O-methyleneadenosin-5?-yl bis-5?-O-methyluridin-3?-yl phosphate (1a) have been followed by RP HPLC over a wide pH range to elucidate the role of the 2?-OH group as an intermolecular hydrogen bond donor facilitating the cleavage of 1a. At pH < 2, where the decomposition of 1 is first-order in hydronium-ion concentration, the P-O5? and P-O3? bonds are cleaved equally rapidly. Over a relatively wide range from pH 2 to 4, the hydrolysis is pH-independent and the P-O5? bond is cleaved 1.6 times as rapidly as the P-O3? bond. At pH 6, the reaction becomes first-order in hydroxide-ion concentration and cleavage of the P-O3? bond starts to predominate, accounting for 89% of the overall hydrolysis in 10 mmol L-1 aqueous sodium hydroxide. Under alkaline conditions, the 2?-OH group facilitates the cleavage of 1 by a factor of 27 compared to the 2?-OMe counterpart, the influence on the P-O3? and P-O5? bond cleavage being equal. Accordingly, the 2?-hydroxy group stabilizes the phosphorane intermediate, not the departing 3?-oxyanion, by hydrogen bonding. If you are interested in 1608-26-0, you can contact me at any time and look forward to more communication.Application of 1608-26-0
Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate