224311-51-7, Name is 2-(Di-tert-Butylphosphino)biphenyl, molecular formula is C20H27P, belongs to chiral-phosphine-ligands compound, is a common compound. In a patnet, once mentioned the new application about 224311-51-7, name: 2-(Di-tert-Butylphosphino)biphenyl
The carbonylative coupling of 1-heptyne (1a) with aniline (2a) has been successfully achieved in the presence of Pd(OAc)2 and a suitable bidentate phosphine ligand and solvent. The gem-alpha,beta-unsaturated amide (3aa) was formed as a predominant product in the presence of the catalytic system Pd(OAc)2/1,3-bis(diphenylphosphino)propane (dppp)/p-toluenesulfonic acid (p-TsOH)/CO in THF as a solvent. While the use Pd(OAc)2 and 1,4-bis(diphenylphosphino)butane (dppb), under syngas (CO/H2) conditions and in CH2Cl2 as a solvent, affords the trans-alpha,beta-unsaturated amide (4aa) as the major product. A minor cyclic product (5aa) was formed via the double carbonylation reaction. The regioselective carbonylative coupling reaction was also successfully applied to N-methyl aniline (2b) with 1-heptyne (1a) producing excellent yields of tertiary unsaturated amides.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: chiral-phosphine-ligands. In my other articles, you can also check out more blogs about 224311-51-7
Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate