224311-51-7, Name is 2-(Di-tert-Butylphosphino)biphenyl, molecular formula is C20H27P, belongs to chiral-phosphine-ligands compound, is a common compound. In a patnet, once mentioned the new application about 224311-51-7, SDS of cas: 224311-51-7
Rh-Catalyzed alkyne-isatin decarbonylative coupling provides an effective method for cleavage of C-C bonds in unstrained five-membered ring compounds. The challenge in this transformation is activation of the less-strained C-C bond, while avoiding competitive C-H activation. We performed DFT calculations to clarify this process to facilitate expansion of this strategy. The calculations show that chemoselectivity switching (C-C versus C-H functionalization) depends on the substituent on the phenyl ring of isatin. The coordination properties of the ligand significantly affect the alkyne insertion step. Dissociation of a strong sigma-donor phosphine ligand from the Rh center to enable alkyne coordination is unfavorable, therefore the subsequent alkyne insertion step has a high energy barrier. Our calculations also explain the experimentally observed regioselectivity, which mainly arises from the interaction energy.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 224311-51-7. In my other articles, you can also check out more blogs about 224311-51-7
Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate