Synthetic Route of 1034-39-5, An article , which mentions 1034-39-5, molecular formula is C18H15Br2P. The compound – Dibromotriphenylphosphorane played an important role in people’s production and life.
Compound that couple molecular recognition of specific alkali metal ions with DNA damage may display selective cleavage of DNA under condition of elevated alkali metal ion level reported to exist in certain cancer cell . We have prepared a homologous serie of compound in which a DNA reactive moiety, a bis (propargylic) sulfone, is incorporated into an alkali metal ion binding crown ether ring. Using the alkali metal ion pricrate extraction assay, the ability of these crown ether to bind Li+, Na+, and K+, ions was determined. For the series of crown ethers , the association constant for Li+ ions are generally low (< 2 x 104M-1). Only two of the bis(propargylic) sulfone crown ethers associate with Na+ or K+ ions (Ka 4 8 x 104M-1), with little discrimination between Na+ or K+ ions. The ability of these compounds to cleave supercoiled DNA at pH 7.4 in the presence of Li+, Na+ , and K+ ions was determined. The two crown ethers that bind Na+ and K+ display a modest increase in DNA cleavage efficiency in the presence of Na+ or K+ ions as compared to Li+ ions. These two bis (propargylic) sulfone crown ethers are also more cytotoxic against a panel of human cancer cell line when compared to a non-crown ether macrocyclic bis(propargylic) sulfone. Copyright I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1034-39-5, help many people in the next few years., Synthetic Route of 1034-39-5
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate