Application of 1608-26-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1608-26-0, Name is Tris(dimethylamino)phosphine
, molecular formula is P[N(CH3)2]3. In a Article，once mentioned of 1608-26-0
The alkaline hydrolysis of the P-chiral cis-nucleoside 3?,5?-cyclic aryl [18O]monophosphates 4a-c and of the unlabeled analogs 3a-c was studied. Hydrolysis of the 18O-labeled phosphate triesters 4a-c yielded three products: 3?,5?-cyclic [18O]phosphate diester, 5?-acyclic aryl [18O]phosphate diester, and 3?-acyclic aryl [18O]phosphate diester. The stereochemistry of the formation of the 3?,5?-cyclic [18O]phosphate diester was determined by means of methylating the hydrolysis products with methyl iodide. The formation of the 3?,5?-cyclic [18O] phosphate diester during hydrolysis of compounds 4a and 4c proceeds with 17% inversion of configuration at phosphorus, whereas 40% inversion is found during hydrolysis of 4b. Inversion of configuration indicates the existence of a PV-TBP with a diequatorially located dioxaphosphorinane ring. Retention of configuration (83% for 4a and 4c, and 60% for 4b) can be explained in terms of Berry pseudorotation. The formation of the 5?-acyclic aryl [18O]phosphate diester during hydrolysis of compounds 4a and 4c proceeds with about 50% inversion of configuration at phosphorus, whereas formation of the 3?-acyclic aryl [18O]phosphate diester proceeds with an inversion/retention ratio of 88:12 or 12:88 for 4a and 79:21 or 21:79 for 4c. It is clear that Berry pseudorotation takes place during hydrolysis of the 3?,5?-cyclic phosphate triesters 4a-c. This is in contrast with earlier hydrolysis studies on 3?,5?-cyclic phosphate diesters proceeding without Berry pseudorotation, leading to complete inversion of configuration at phosphorus. Because of the very small amounts of 3?- and 5?-acyclic aryl [18O]phosphate diesters formed during the hydrolysis reaction of compound 4b, the stereochemistry could not be determined. The hydrolysis reactions, which have been studied on the unlabeled compounds 3a-c, obey second-order kinetics. Changing the ribose ring to a deoxyribose ring or changing the adenine base to thymine in the 3?,5?-cyclic phosphate triester does not dramatically influence the second-order reaction rate constant. However, the nature of the P-OR substituent significantly influences the reaction rate. The 3?,5?-cyclic phosphate triester with p-nitrophenoxy as substituent hydrolyzes approximately 18 times (T = 294 K) faster than the corresponding triester with phenoxy as substituent.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1608-26-0 is helpful to your research., Application of 1608-26-0
Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate