Electric Literature of 1608-26-0. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1608-26-0, Name is Tris(dimethylamino)phosphine
Hydrolytic reactions of 2?,3?-O-methyleneadenos-5?-yl 2?,5?-di-O-methylurid-3?-yl 5?-O-methylurid- 3?(2?)-yl phosphate (1a,b) have been followed by RP-HPLC over a wide pH range to evaluate the feasibility of occurrence of phosphate-branched RNA under physiological conditions. At pH <2, where the decomposition of 1a,b is first order in [H3O+], the P-O5? bond is cleaved 1.5 times as rapidly as the P-O3? bond. Under these conditions, the reaction probably proceeds by an attack of the 2?-OH on the phosphotriester monocation. Over a relatively wide range from pH 2 to 5, the hydrolysis is pH-independent, referring to rapid initial deprotonation of the attacking 2?-OH followed by general acid catalyzed departure of the leaving nucleoside. The P-O5? bond is cleaved 3 times as rapidly as the P-O3? bond. At pH 6, the reaction becomes first order in [HO-], consistent with an attack of the 2?-oxyanion on neutral phosphate. The product distribution is gradually inversed: in 10 mmol L-1 aqueous sodium hydroxide, cleavage of the P-O3? bond is favored over P-O5? by a factor of 7.3. The results of the present study suggest that the half-life for the cleavage of 1a,b under physiological conditions is only 100 s. Even at pH 2, where 1a,b is most stable, the half-life for its cleavage is less than one hour and the isomerization between la and 1b is even more rapid than cleavage. The mechanisms of the partial reactions are discussed. The Royal Society of Chemistry 2005. If you are hungry for even more, make sure to check my other article about 1608-26-0. Electric Literature of 1608-26-0
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate