Related Products of 1608-26-0. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1608-26-0, Name is Tris(dimethylamino)phosphine
Synthesis and conformational analysis of phosphorus-derivatized no-base analogues of 3′,5′-cyclic nucleotides
A number of epimeric pairs of 3-X-3-oxo-trans-2,4,7-trioxa-3-phosphabicyclo<4.3.0>-nonanes <5, X=OCH3; X=OPh; 7, X=Cl; 8, X=N(CH3)2; 9, X=S(1-); 10, X=O(1-)> have been prepared as no-base analogues of 3′,5′-cyclic nucleotides. 1H NMR analysis shows the phosphate ring of the cis diastereomers (relationship of singly bonded substituent on phosphorus and proton H1) 5a-7a, 9a and 10 and the trans diastereomers 8b and 9b to be in chair conformation 15.The phosphate rings of the epimers 5b-7b and 8a exist as an equilibrium between chair conformation 15 and twist conformation 16.The mole fraction of twist depends on the nature of singly bonded substituent and varies from about 0.3 for 5b to 0.8 for 7b.The close similarity in coupling constants of the tetrahydrofuran ring of the phosphates 5-10 indicates that the population of a twist conformer has little effect on the conformation of this ring, which is close to 4E-4T3.The results obtainaed for 5-10 are compared with those of conformational studies on corresponding phosphates derived from thymidine and cyclopentane.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate