Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 7650-91-1, Name is Benzyldiphenylphosphine, Safety of Benzyldiphenylphosphine.
Method for preparation of tertiary phosphines via nickel-catalyzed cross coupling
The invention is an improved method for the preparation of tertiary phosphines by way of cross-coupling of aryl, alkenyl, cycloalkenyl or aralkyl halides or aryl, alkenyl, cycloalkenyl or aralkyl sulfonate esters with chlorophosphines in the presence of a catalyst and a reductant. The general reaction scheme is shown below: STR1 wherein R1 is aryl, alkenyl, cycloalkenyl or aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl, or CONR4 R5 wherein R4 and R5 are independently hydrogen, alkyl, aryl or aralkyl; R2 and R3 are independently aryl, alkyl, aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl or CoNR4 R5 wherein R4 and R5 are independently hydrogen, alkyl, aryl or aralkyl; and n is 2 where R1 is a difunctional moiety and 1 for any other R1 ; and X is Cl, Br, I, or OSO2 Y; wherein Y is alkyl, trihalomethyl, phenyl, halophenyl, or alkylphenyl.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of Benzyldiphenylphosphine. In my other articles, you can also check out more blogs about 7650-91-1
Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate