Chemistry is an experimental science, Application In Synthesis of 3,3′,3”-Phosphinetriyltripropanoic acid hydrochloride, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 51805-45-9, Name is 3,3′,3”-Phosphinetriyltripropanoic acid hydrochloride, molecular formula is C9H16ClO6P, belongs to chiral-phosphine-ligands compound. In a document, author is Xu, Dongmin.
Enantiodivergent Formation of C-P Bonds: Synthesis of P-Chiral Phosphines and Methylphosphonate Oligonucleotides
Phosphorus Incorporation (PI, abbreviated Pi) reagents for the modular, scalable, and stereospecific synthesis of chiral phosphines and methylphosphonate nucleotides are reported. Synthesized from translimonene oxide, this reagent class displays an unexpected reactivity profile and enables access to chemical space distinct from that of the Phosphorus-Sulfur Incorporation reagents previously disclosed. Here, the adaptable phosphorus(V) scaffold enables sequential addition of carbon nucleophiles to produce a variety of enantiopure C-P building blocks. Addition of three carbon nucleophiles to Pi, followed by stereospecific reduction, affords useful P-chiral phosphines; introduction instead of a single methyl group reveals the first stereospecific synthesis of methylphosphonate oligonucleotide precursors. While both. enantiomers are available, only one isomer is required.the order of nucleophile addition controls the absolute stereochemistry of the final product through a unique enantiodivergent design.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 51805-45-9. Application In Synthesis of 3,3′,3”-Phosphinetriyltripropanoic acid hydrochloride.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate