Electric Literature of 6224-63-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 6224-63-1, Name is Tri-m-tolylphosphine, SMILES is CC1=CC(P(C2=CC=CC(C)=C2)C3=CC=CC(C)=C3)=CC=C1, belongs to chiral-phosphine-ligands compound. In a article, author is Xiao, Ben-Xian, introduce new discover of the category.
Phosphine-catalysed asymmetric dearomative formal [4+2] cycloadditions of 3-benzofuranyl vinyl ketones
In contrast to the catalytic asymmetric dearomative reactions of indole substrates, those of the analogous benzofuran derivatives have been less explored. Here we report that the stereoselective domino Rauhut-Currier/Michael addition process of 3-benzofuranyl vinyl ketones and 3-olefinic (7-aza) oxindoles can be realised via catalysis by a chiral bifunctional phosphine, furnishing the previously unreported direct asymmetric dearomative reaction of benzofuran substrates tethered to a carbonyl group in a formal [4+ 2] cycloaddition manner. An array of hydrodibenzofuran derivatives with dense substitutions is generally constructed with excellent diastereoselectivity and enantioselectivity (up to >19 : 1 dr, >99% ee).
Electric Literature of 6224-63-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 6224-63-1 is helpful to your research.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate