Chemistry is an experimental science, Computed Properties of C18H12F3P, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 18437-78-0, Name is Tris(4-fluorophenyl)phosphine, molecular formula is C18H12F3P, belongs to chiral-phosphine-ligands compound. In a document, author is Rexiti, Rukeya.
Copper-catalyzed enantioselective 1,4-conjugate addition of dialkylzinc reagents to alpha,beta- and alpha,beta,gamma,delta-unsaturated ketones
An enantioselective Cu(II)-catalyzed conjugate addition of dialkylzinc reagents to alpha,beta- or alpha,beta,gamma,delta-unsaturated ketones with chiral cyclohexane-based amidophosphine ligands was developed. With 2 mol% of Cu(OAc)(2)center dot H2O/L5, the conjugate addition of diethylzinc to alpha,beta-unsaturated ketones was achieved in good-to-excellent yields (up to 98%) and high enantioselectivities (up to 92% ee). This catalytic system was shown to be efficient for the 1,4-conjugate addition of Et2Zn to (2E,4E)-1,5-diphenylpenta-2,4-dien-1-one with 85% yield and 90% ee. Moreover, with 1 mol% of Cu(OTf)(2)/L11, the conjugate addition of alpha,beta,gamma,delta-unsaturated ketones was accomplished with 1,4-regioselectivity, good yields (79-86%) and excellent enantioselectivities (up to 97% ee). (C) 2019 Elsevier Ltd. All rights reserved.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 18437-78-0, in my other articles. Computed Properties of C18H12F3P.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate