In an article, author is Hu, Xin-Hu, once mentioned the application of 791-28-6, Product Details of 791-28-6, Name is Triphenylphosphine oxide, molecular formula is C18H15OP, molecular weight is 278.2849, MDL number is MFCD00002080, category is chiral-phosphine-ligands. Now introduce a scientific discovery about this category.
Highly Diastereo- and Enantioselective Ir-Catalyzed Hydrogenation of 2,3-Disubstituted Quinolines with Structurally Fine-Tuned Phosphine-Phosphoramidite Ligands
A highly diastereo- and enantioselective Ir-catalyzed hydrogenation of unfunctionalized 2,3-disubstituted quinolines, especially 3-alkyl-2-arylquinolines, has been realized. The success of this hydrogenation is ascribed to the use of a structurally fine-tuned chiral phosphine phosphoramidite ligand with a (S-a)-3,3′-dimethyl H-8-naphthyl moiety and (R-c)-1-phenylethylamine backbone. The hydrogenation displayed broad functional group tolerance, thus furnishing a wide range of optically active 2,3-disubstituted tetrahydroquinolines in up to 96% ee and with perfect cis-diastereoselectivity.
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Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate