Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Urano, Chisato, once mentioned the application of 6372-42-5, Name is Cyclohexyldiphenylphosphine, molecular formula is C18H21P, molecular weight is 268.3331, MDL number is MFCD00046360, category is chiral-phosphine-ligands. Now introduce a scientific discovery about this category, Quality Control of Cyclohexyldiphenylphosphine.
Asymmetric allylic substitution by chiral palladium catalysts: Which is more reactive, major pi-allyl Pd(II) species or minor pi-allyl species?
The reactivity difference of major and minor n-allyl species was examined for two typed asymmetric allylic substitutions via linear symmetrical pi-allyl and linear unsymmetrical pi-allyl intermediates. P-31 NMR observation of the stoichiometric reaction of [Pd(1,3-diphenyl-pi-allyl)(N-P-N-type ligand)](+) with malonate ion verified that major species was much more reactive than the minor one. In the case of the reaction of [Pd(1,1,3-trimethyln-allyl)((S)-BINAP)](+) species with soft amido ion, increase in the minor/major ratio of the n-allyl species afforded higher enantioselectivity to indicate that the minor pi-allyl was more reactive than the major one.
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Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate