Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 18437-78-0, Name is Tris(4-fluorophenyl)phosphine, SMILES is FC1=CC=C(P(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)C=C1, belongs to chiral-phosphine-ligands compound. In a document, author is Xi, Yumeng, introduce the new discover, Computed Properties of C18H12F3P.
Catalytic asymmetric addition of an amine N-H bond across internal alkenes
Hydroamination of alkenes, the addition of the N-H bond of an amine across an alkene, is a fundamental, yet challenging, organic transformation that creates an alkylamine from two abundant chemical feedstocks, alkenes and amines, with full atom economy(1-3). The reaction is particularly important because amines, especially chiral amines, are prevalent substructures in a wide range of natural products and drugs. Although extensive efforts have been dedicated to developing catalysts for hydroamination, the vast majority of alkenes that undergo intermolecular hydroamination have been limited to conjugated, strained, or terminal alkenes(2-4); only a few examples occur by the direct addition of the N-H bond of amines across unactivated internal alkenes(5-7), including photocatalytic hydroamination(8,9), and no asymmetric intermolecular additions to such alkenes are known. In fact, current examples of direct, enantioselective intermolecular hydroamination of any type of unactivated alkene lacking a directing group occur with only moderate enantioselectivity(10-13). Here we report a cationic iridium system that catalyses intermolecular hydroamination of a range of unactivated, internal alkenes, including those in both acyclic and cyclic alkenes, to afford chiral amines with high enantioselectivity. The catalyst contains a phosphine ligand bearing trimethylsilyl-substituted aryl groups and a triflimide counteranion, and the reaction design includes 2-amino-6-methylpyridine as the amine to enhance the rates of multiple steps within the catalytic cycle while serving as an ammonia surrogate. These design principles point the way to the addition of N-H bonds of other reagents, as well as O-H and C-H bonds, across unactivated internal alkenes to streamline the synthesis of functional molecules from basic feedstocks. Hydroamination with high enantio- and regioselectivity is achieved across a wide range of internal alkenes by using a cationic iridium complex that adds an ammonia surrogate containing a pyridine group.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 18437-78-0 is helpful to your research. Computed Properties of C18H12F3P.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate