Synthetic Route of 6372-42-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 6372-42-5, Name is Cyclohexyldiphenylphosphine, SMILES is C1CCC(CC1)P(C1=CC=CC=C1)C1=CC=CC=C1, belongs to chiral-phosphine-ligands compound. In a article, author is Zheng, Sheng-Cai, introduce new discover of the category.
Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrroles
We report herein the first examples of catalytic enantioselective synthesis of axially chiral 3-arylpyrroles. Reaction of alpha-isocyanoacetates with beta-aryl-alpha,beta-alkynic ketones in the presence of silver oxide and a phosphine ligand derived from Cinchona alkaloid occurred chemoselectively to afford enantioenriched 3-arylpyrroles in high yields with excellent enantiomeric excesses. The pyrrole ring was constructed de novo in this process.
Synthetic Route of 6372-42-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 6372-42-5 is helpful to your research.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate