Application of 51805-45-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 51805-45-9.
Application of 51805-45-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 51805-45-9, Name is 3,3′,3”-Phosphinetriyltripropanoic acid hydrochloride, SMILES is Cl[H].OC(=O)CCP(CCC(O)=O)CCC(O)=O, belongs to chiral-phosphine-ligands compound. In a article, author is Major, Mate Miklos, introduce new discover of the category.
Double stereoselective coordination of chiral N,S ligands: Synthesis, coordination chemistry and utilization in Pd-catalyzed allylic alkylation
A series of chiral pentane-2,4-diyl-based thioether-amine ligands [4 and 5; (R,S)- and (S,S)-(RSCH)-S-1(CH3)CH2CH(CH3)NHR2, respectively, where 4a R-1 = iPr, R-2 = Ph; 4b R-1 = tBu, R-2 = Ph; 4c R-1 = 1-Ad, R-2 = Ph; 5a R-1 = iPr, R-2 = Ph; 5b R-1 = tBu, R-2 = Ph; 5c R-1 = 1-Ad, R-2 = Ph; 5d R-1 = iPr, R-2 = 4-MeOC6H4; 5e R-1 = iPr, R-2 = 4-MeC6H4; 5f R-1 = iPr, R-2 = 3,5-Me2C6H3] with stereogenic S- and N-donor atoms has been prepared starting from cyclic sulfates via optically pure gamma-aminoalcohol or 2,4-dimethylazetidine intermediates. The synthesis of the novel diastereomerically related ligand sets 4 and 5 was accomplished starting from the same source of chirality. The modular ligand structure and the novel synthetic strategies developed for their synthesis allowed the easy modification of the ligands’ (i) S- and (ii) N-substituents, as well as (iii) the relative stereochemistry within the ligand backbone. Six-membered [Pd(N,S)Cl-2]-type chelate complexes of the diastereomerically related ligands 4a and 5a were synthesized and characterized by X-ray crystallography in the solid phase, by density functional theory calculations and in solution by NMR spectroscopy. The coordination of 5a resulted in the formation of a single chair conformation by the stereospecific locking of both stereolabile (N and S) donor atoms. In contrast, compound 4a forms rapidly equilibrating palladium species due to the fast inversion of the sulfur donor. Ligands with stereochemically fixed donor atoms provided robust and efficient catalytic systems that can be effectively applied in alkylene carbonates as green reaction media. Remarkably, the phosphine-free catalysts are air-stable, and at room temperature in the presence of moisture gave excellent ee’s (up to 93%) in asymmetric allylation processes thanks to the double stereoselective coordination.
Application of 51805-45-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 51805-45-9.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate