Synthetic Route of 6372-42-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 6372-42-5, Name is Cyclohexyldiphenylphosphine, SMILES is C1CCC(CC1)P(C1=CC=CC=C1)C1=CC=CC=C1, belongs to chiral-phosphine-ligands compound. In a article, author is Cheng, Yuyu, introduce new discover of the category.
Phosphine-mediated enantioselective [4+1] annulations between ortho-quinone methides and Morita-Baylis-Hillman carbonates
The first example of phosphine catalyzed enantioselective [4 + 1] annulations of ortho-quinone methides and Morita-Baylis-Hillman carbonates is described. In the presence of 1,2-bis[(2R,5R)-2,5-dimethylphospholano]benzene monoxide, Morita-Baylis-Hillman carbonates reacted with ortho-quinone methides smoothly to afford a series of optically active 2,3-dihydrobenzofurans in 32-67% yields with 88-94% ee and >20:1 dr. When (-)-1,2-bis[(2R,5R)-2,5-dimethylphospholano]benzene was employed as a catalyst, the [4 + 1] annulation between ortho-quinone methides and Morita-Baylis-Hillman carbonates furnished chiral 2,3-dihydrobenzofurans in 65-90% yields with 79-87% ee and >20:1 dr. This protocol represents a facile strategy for the synthesis of biologically important enantioenriched 2,3-dihydrobenzofurans.
Synthetic Route of 6372-42-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 6372-42-5 is helpful to your research.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate