Chemistry is an experimental science, Recommanded Product: Tris(4-fluorophenyl)phosphine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 18437-78-0, Name is Tris(4-fluorophenyl)phosphine, molecular formula is C18H12F3P, belongs to chiral-phosphine-ligands compound. In a document, author is Takata, Tatsuaki.
Synthesis of alpha-Aminophosphines by Copper-Catalyzed Regioselective Hydroamination of Vinylphosphines
A copper-catalyzed net hydroamination of vinyl-phosphine boranes with hydrosilanes and O-benzoylhy-droxylamines has been developed. The reaction proceeds regioselectively to form the corresponding alpha-aminophosphine boranes of potent interest in medicinal and pharmaceutical chemistry. This copper catalysis is based on an umpolung, electrophilic amination strategy and provides a new electrophilic amination approach to alpha-aminophosphine derivatives. Additionally, although still preliminary, asymmetric synthesis has also been achieved by judicious choice of a chiral bisphosphine-ligated copper complex.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 18437-78-0, in my other articles. Recommanded Product: Tris(4-fluorophenyl)phosphine.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate