Chemistry is an experimental science, COA of Formula: C18H15OP, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 791-28-6, Name is Triphenylphosphine oxide, molecular formula is C18H15OP, belongs to chiral-phosphine-ligands compound. In a document, author is Ni, Huanzhen.
Highly Enantioselective [3+2] Annulation of 3-Butynoates with beta-Trifluoromethyl Enones Promoted by an Amine-Phosphine Binary Catalytic System
We report a highly enantioselective [3 + 2] annulation between 3-butynoates and beta-trifluoromethyl enones, furnishing trifluoromethylated cyclopentenes with three contiguous stereogenic centers in good yields, high diastereoselectivities, and excellent enantioselectivities. A unique catalytic system consisting of a simple amine and a chiral phosphine was devised, and the synergistic play of Lewis basic amine and phosphine was crucial for alkyne isomerization and subsequent cyclization. The protocol disclosed herein allows facile activation of 3- butynoates in phosphine-mediated asymmetric transformations.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 791-28-6. COA of Formula: C18H15OP.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate