Related Products of 6372-42-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 6372-42-5, Name is Cyclohexyldiphenylphosphine, SMILES is C1CCC(CC1)P(C1=CC=CC=C1)C1=CC=CC=C1, belongs to chiral-phosphine-ligands compound. In a article, author is Wang, Ge, introduce new discover of the category.
Copper-Phosphido Intermediates in Cu(IPr)-Catalyzed Synthesis of 1-Phosphapyracenes via Tandem Alkylation/Arylation of Primary Phosphines
Tandem alkylation/arylation of primary phosphines PH2R (R = Ph, Cy, Fc, FcCH(2); Fc = ferrocenyl) with 5-bromo-6-chloromethylacenaphthene (1) and 2 equiv of NaOSiMe3 using the catalyst precursor Cu(IPr)(Cl) gave a series of 1-phosphapyracenes (R-PyraPhos, 2a-d), which were isolated as borane adducts 3a-d. Similar reactions of the chiral air-stable primary phosphines PH2Ar* (Ar* = (S)-binaphthyl (4), (R)-MeO-binaphthyl (5)) to yield 2e,f and 3e,f were diastereoselective (dr = 2:1 and 1.2:1, respectively), and chromatography gave a highly enriched sample of one diastereomer of 3f. The mechanism of catalysis was investigated by NMR monitoring and independent syntheses of potential intermediates. The phosphido complexes Cu(IPr)(PHAr’) (Ar’ = Ph, (R)-MeO-binaphthyl) were generated in equilibrium mixtures, along with Me3SiOH, from Cu(IPr)(OSiMe3) and PH2Ar’. They reacted with benzyl chloride 1 to yield Cu(IPr)(Cl) and the secondary phosphines PHAr’ (CH2Ar) (Ar = Br-acenaphthyl); addition of NaOSiMe3 yielded PyraPhos derivatives 2a,f Deprotonation of the cations [Cu(IPr)(PHAr’CH2 Ar)][OTf] (Ar’ = Ph, (R)-MeO-binaphthyl) was investigated as a route to the secondary phosphido complexes Cu(IPr)(PAr’CH2Ar) (13). We propose that C-Br oxidative addition in the Cu(I)-phosphido intermediates 13 followed by P-C reductive elimination from Cu(III)-phosphido complexes forms the PyraPhos ring, with diastereoselection arising from rapid pyramidal inversion of Cu-phosphido groups.
Related Products of 6372-42-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 6372-42-5 is helpful to your research.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate