One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 791-28-6, Name is Triphenylphosphine oxide, formurla is C18H15OP. In a document, author is Saito, Akari, introducing its new discovery. Product Details of 791-28-6.
Catalytic Hydrogenation of N-protected alpha-Amino Acids Using Ruthenium Complexes with Monodentate Phosphine Ligands
A ruthenium complex with a monodentate phosphine ligand was used to catalytically hydrogenate N-protected alpha-amino acids under essential retention of the configuration of their alpha-chiral centers. Among the ligands tested for this hydrogenation, which proceeds at a relatively low temperature, tris(para-fluorophenyl)phosphine exhibited the best performance. In comparison, electron-rich monodentate, bidentate, and tridentate phosphines were far less effective. The precatalyst Ru(OAc)(2)[(p-FC6H4)(3)P](2) was synthesized and isolated, and its structure was determined by a single-crystal X-ray diffraction analysis. N-protected alpha-amino acids with neutral alkyl side chains, including polar functional groups such as sulfides, indoles, ethers, phenols, pyrroles, and arenes, are compatible with the applied hydrogenation conditions, affording the corresponding optically active 2-substituted-2-(1H-pyrrol-1-yl)ethan-1-ol (2-amino ethanol) derivatives in moderate to high yield.
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Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate