Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 6372-42-56372-42-5, Name is Cyclohexyldiphenylphosphine, SMILES is C1CCC(CC1)P(C1=CC=CC=C1)C1=CC=CC=C1, belongs to chiral-phosphine-ligands compound. In a article, author is Cui, Hai-Lei, introduce new discover of the category.
Catalyst-Free Synthesis of Novel Dimeric Tetrahydroisoquinoline Derivatives through [2+2+2] Annulation
A simple, straightforward, and atom economic catalyst-free [2+2+2] annulation of dihydroisoquinolines and allenoates has been developed. A diverse range of novel dimeric tetrahydroisoquinoline derivatives can be prepared in moderate to good yields (37-87 %) from readily available material. Dihydro-beta-carboline can also be used in this reaction system delivering corresponding dimeric dihydro-beta-carboline derivatives. Notably, the reaction could be easily scaled up to gram scale. The easy scale-up of this process may provide structurally diversified natural product-like molecules possessing privileged scaffold for potential application in biomedical research and other research fields. Interestingly, in contrast to the alpha,beta-selectivity observed in our previous study, beta,gamma-selective [2+2+2] annulation was preferred in this work.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 6372-42-5. Recommanded Product: 6372-42-5.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate