Reference of 51805-45-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 51805-45-9, Name is 3,3′,3”-Phosphinetriyltripropanoic acid hydrochloride, SMILES is Cl[H].OC(=O)CCP(CCC(O)=O)CCC(O)=O, belongs to chiral-phosphine-ligands compound. In a article, author is Li, Shasha, introduce new discover of the category.
Preparation and Application of Amino Phosphine Ligands Bearing Spiro[indane-1,2 ‘-pyrrolidine] Backbone
P,N-sp3-bidentate chiral ligands bearing spiro[indane-1,2’-pyrrolidine] backbone were prepared in gram scale for the first time. Pd complexes of these air-stable amino phosphine ligands could catalyze asymmetric allylic substitutions of malonate-, alcohol-, and amine-type nucleophiles in up to 97% ee and 99% yield. A crystal structure of [Pd(II)(eta(3)-1,3-diphenylallyl)(ligand)]PF6 indicated possible transition states of the catalytic reactions. These ligands are characteristic of a very rigid backbone, which is simple but highly effective. They rival C-2-symmetric bisphosphine, P,N-sp2-bidentate, and P,N-sp3-bidentate ligands in tested allylic substitutions.
Reference of 51805-45-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 51805-45-9.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate