A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, SDS of cas: 1486-28-8, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1486-28-8, Name is Methyldiphenylphosphine, molecular formula is C13H13P. In an article, author is Facchetti, Giorgio,once mentioned of 1486-28-8.
Asymmetric Hydrogenation of 1-aryl substituted-3,4-Dihydroisoquinolines with Iridium Catalysts Bearing Different Phosphorus-Based Ligands
Starting from the chiral 5,6,7,8-tetrahydroquinolin-8-ol core, a series of amino-phosphorus-based ligands was realized. The so-obtained amino-phosphine ligand (L1), amino-phosphinite (L2) and amino-phosphite (L3) were evaluated in iridium complexes together with the heterobiaryl diphosphines tetraMe-BITIOP (L4), Diophep (L5) andL6andL7ligands, characterized by mixed chirality. Their catalytic performance in the asymmetric hydrogenation (AH) of the model substrate 6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline1aled us to identify Ir-L4and Ir-L5catalysts as the most effective. The application of these catalytic systems to a library of differently substituted 1-aryl-3,4-dihydroisoquinolines afforded the corresponding products with variable enantioselective levels. The 4-nitrophenyl derivative3bwas obtained in a complete conversion and with an excellent 94% e.e. using Ir-L4,and a good 76% e.e. was achieved in the reduction of 2-nitrophenyl derivative6ausing Ir-L5.
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Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate