In an article, author is Mino, Takashi, once mentioned the application of 6224-63-1, Recommanded Product: Tri-m-tolylphosphine, Name is Tri-m-tolylphosphine, molecular formula is C21H21P, molecular weight is 304.37, MDL number is MFCD00008532, category is chiral-phosphine-ligands. Now introduce a scientific discovery about this category.
N,N-Disubstituted Allylic Amine Type Aminophosphines with C(aryl)-N(amine) Bond Axial Chirality: Synthesis and Application to Palladium-Catalyzed Asymmetric Allylic Alkylation with Malonates
We designed and synthesized a series of N,N-disubstituted allylic amine type aminophosphines 2, 3 and 4, which are derivatives of chiral ligands 1. Aminophosphines 2-4 (except 2a) exist in C(aryl)- N(amine) bond axial chirality by chiral HPLC analysis. Both enantiomeric isomers of 4b were successfully obtained in an enantiomerically pure form. We demonstrated that 1a, 1b, and 4b can be used as effective chiral ligands for the palladium-catalyzed asymmetric ally lie alkylation of 1,3-diphenyl-2-propenyl acetate with malonates in high enantioselectivities (up to 90% ee).
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Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate