Synthetic Route of 1608-26-0, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.1608-26-0, Name is Tris(dimethylamino)phosphine
, molecular formula is P[N(CH3)2]3. In a patent, introducing its new discovery.
THIONO COMPOUNDS. 8. MUTAGENIC ACTIVITY OF REPRESENTATIVE AMIDES OF THIOPHOSPHORIC ACID
Amides of thiophosphoric acid were studied, in order to initiate correlations of mutagenicity with structure, by use of a modified Ames assay.Representative thiophosphoramides of the structure (XArNH)3PS were not mutagenic, irrespective of whether X was a reference hydrogen atom, an electron-withdrawing, or an electron-donating group.One phosphoramidothioate of the structure (2,4-X2ArNH)P(S)(OCH2CH3)2 effected base-pair mutation when X was F (but not when X was CH3), when S-9 liver homogenate with exogenous NADP was used; when X was H, only inconsistent mutagenic activity following metabolic activation was observed even at concentrations near those that produced acute cellular toxicity.Mutagenicity of these N-arylamides thus appears to follow guidelines concluded for esters, (RO)3PS, i.e. that mutagenesis is most probable when two groups are small enough to permit nucleophilic attack by a biomacromolecule on the electrophilic phosphorus atom.That the third group should be electron withdrawing again seems important although it need not be a good leaving group.An alkyl thionamide, <(CH3)2N>3PS, resembled the oxygen counterpart, <(CH3)2N>3PO, to which it probably is biotransformed, in being only marginally mutagenic.We conclude that the hazard of mutagenesis is likely to be less with amides than with esters of thiophosphoric acid and that most of the representative thioamides tested are unlikely to pose serious mutagenic hazards. – Key Words: Ames assay, base-pair mutation, mutagenesis, phosphoramidothioate, thionamide, thiophosphoramide
If you are interested in 1608-26-0, you can contact me at any time and look forward to more communication.Synthetic Route of 1608-26-0
Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate