Synthetic Route of 17261-28-8. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 17261-28-8, Name is 2-(Diphenylphosphino)benzoic acid. In a document type is Patent, introducing its new discovery.
A 2 – carbonyl – 4 – alkyl – 4 – alkyl – 5 – bromo – 1, 3 – oxazine compounds and its synthesis method (by machine translation)
The invention discloses a 2 – carbonyl – 4 – alkyl – 4 – alkyl – 5 – bromo – 1, 3 – oxazine compounds and its synthesis method. 2 – carbonyl – 4 – alkyl – 4 – alkyl – 5 – bromo – 1, 3 – oxazine shown as formula II, wherein R1 For C1 – C5 Alkyl, aryl or substituted aryl group; R2 For C1 – C5 Alkyl; Ts expressed paratoluene sulfonyl. The invention also provides a compound of formula II shown in preparation method, comprises the following steps: in the sulfonic acid scandium trifluoromethanesulfonate, phosphorus ligand and under the action of the potassium bromide, of a compound of formula I 1, 3 – dibromo – 5, 5 – dimethyl hydantoin by asymmetric halogen amine cyclization reaction to get the. The invention to different structure of formula I shown to N – toluene sulfonyl amino gao xi terephthalate and dibromodiphenyl a rifampicin because raw materials, in trifluoromethanesulfonic acid scandium/phosphorus ligand and under the action of the potassium bromide, effective to synthesize 2 – carbonyl – 4 – alkyl – 4 – alkyl – 5 – bromo – 1, 3 – oxazine. The invention of the preparation method of the raw material is easy synthesis, mild reaction conditions, the operation is simple, regional high selectivity, enantiomer excess can be as high as 98%, yield as high as 90%. (by machine translation)
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Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate