In an article, published in an article, once mentioned the application of 131274-22-1, Name is Tri-tert-butylphosphonium tetrafluoroborate,molecular formula is C12H28BF4P, is a conventional compound. this article was the specific content is as follows.name: Tri-tert-butylphosphonium tetrafluoroborate
Development of a scalable route to a dual NK-1/serotonin receptor antagonist
The evolution of a process for the preparation of a new heterocyclic dual NK1/serotonin receptor antagonist is described. The final synthesis features a telescoped sequence in which an iron(III)-catalyzed Grignard coupling is followed by a benzylic chlorination utilizing trichlorocyanuric acid to construct an unsymmetrical 2,4,6-trisubstituted pyridine. Etherification of a 4,4?-arylhydroxymethane substituted piperidine fragment completes the synthesis of the active pharmaceutical ingredient in 44% overall yield.
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Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate