Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1608-26-0, Name is Tris(dimethylamino)phosphine
, Computed Properties of P[N(CH3)2]3.
Chemoselective phosphine-catalyzed cyanoacylation of alpha-dicarbonyl compounds: a general method for the synthesis of cyanohydrin esters with one quaternary stereocenter
A chemoselective phosphine-catalyzed cyanoacylation of alpha-dicarbonyl compounds is reported. Under the catalysis of P(NMe2)3, the cyanoacylation of alpha-dicarbonyl compounds such as isatins, alpha-keto esters, and alpha-diketones with acyl cyanides exclusively proceeds under very mild conditions, affording a wide range of cyanohydrin esters bearing one quaternary stereocenter in moderate to excellent yields. It represents the first phosphine-catalyzed cyanoacylation of alpha-dicarbonyl compounds and also provides a general method to prepare fully substituted cyanohydrin esters.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of P[N(CH3)2]3. In my other articles, you can also check out more blogs about 1608-26-0
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate