Synthetic Route of 12150-46-8. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene
Synthesis, characterization, X-ray structure and preliminary in vitro antitumor activity of the nitrosyl complex fac-[RuCl3(NO)(dppf)], dppf = 1,1?-bis(diphenylphosphine)ferrocene
The reaction of RuCl3NO ¡¤ 2H2O with stoichiometric amount of dppf, 1,1?-bis(diphenylphosphino)ferrocene, afforded the new neutral nitrosyl complex fac-[RuCl3(NO)(dppf)] which was characterized by spectroscopical, electrochemical and X-ray crystallography techniques as well as elemental analysis. The nuNO band in the IR spectrum is at 1860 cm-1 (CH2Cl2 solution) and in the cyclic voltammogram an irreversible wave was observed at -1.35 V, both are characteristics of a nitrosonium (NO+) character for the coordinated NO. Additionally, preliminary in vitro antitumor activity against the MDA-MB-231 breast tumor cell line was carried out for the new complex. The initial results indicated an important activity for fac-[RuCl3(NO)(dppf)] (IC50 = 10 ¡À 3 muM ). The complex has a higher cytotoxicity than the precursor complex RuCl3NO ¡¤ 2H2O, the free dppf ligand as well as the reference metallodrug cisplatin.
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Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate