1608-26-0. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 1608-26-0, Name is Tris(dimethylamino)phosphine
. In a document type is Article, introducing its new discovery.
Hydrolysis of 2?,3?-O-methyleneadenos-5?-yl Bis(2?,5?-di-O-methylurid-3?-yl) Phosphate, A Sugar O-Alkylated Trinucleoside 3?,3?,5?-Monophosphate: Implications for the Mechanism of Large Ribozymes
Hydrolytic reactions of 2?,3?-O-methyleneadenos-5?-yl bis(2?,5?-di-O-methylurid-3?-yl) phosphate (1), a sugar O-alkylated trinucleoside 3?,3?,5?-monophosphate, have been followed by RP HPLC over a wide pH range. Under neutral and mildly acidic conditions, the only reaction observed was a pH-independent cleavage of the O-C5? bond of the 5?-linked nucleoside. Under more alkaline conditions nucleophilic attack by hydroxide ion starts to compete. The reaction is first order in [OH-] and becomes predominant at pH 10. Each of the 3?-linked nucleosides is displaced 2.9 times as readily as the 5?-linked one. To determine the betalg value for the hydroxide ion catalyzed hydrolysis of 1, two diesters (2a,b) having 2?,3?-O-methyleneadenosine (7) and 2?,5? -di-O-methyluridine (4) as leaving groups were hydrolyzed under alkaline conditions. Since the betalg value for this reaction is known, DeltapKa between 4 and 7 could be calculated. The beta lg for the hydrolysis of 1 was estimated to be -0.5 with use of this information. The mechanisms of the partial reactions and the role of leaving group properties in ribozyme reactions of large ribozymes are discussed.
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Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate