Month: November 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932710-63-9,4-(Di-tert-butylphosphino)-N,N-dimethylaniline,as a common compound, the synthetic route is as follows.

932710-63-9, To a solution of 0.051 g (0.1 mmol) Hg(SePh)2 in 6 mL DMFwere added 0.026 g (0.1 mmol) of PR2R’ (R = tert-butyl; R’ = 4-N,N-dimethylaniline), and the solution was stirred for 1 h. Thesolution was then filtered over Celite, and 6 mL isopropanol waslayered over the mother liqour. After 3 days, yellow crystals suitablefor X-ray analysis were obtained. Yield: 0.047 g, 61% basedon Hg(SePh)2.Properties: yellow crystalline substance. Melting point: 190-192 C. Anal. Calc. for C56H76Hg2N2P2Se4 (1556,14): Hg, 25.78; Se,20.30; C, 43.22; H, 4.92; N, 1.80. Found: Hg, 25.73; Se, 20.26; C,43.15; H, 4.86; N, 1.71%. IR (KBr): 3040 [vs(CAH)]; 2945 [vas(CH3)];2868 [vs(CH3)]; 1596, 1471, 1435 [vs(CC)]; 1361 [v(CAN)]; 1068,1019 [dip(CCAH)]; 735, 694 [dop(CCAH)]; 505 [v(PAC)];460 cm1 [dop(CCAC)] (dip and dop = in-plane and out-of-planebending motions, respectively).

932710-63-9 4-(Di-tert-butylphosphino)-N,N-dimethylaniline 11714598, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Stieler, Rafael; Faoro, Eliandro; Cechin, Camila Nunes; Floriano, Luana; Lang, Ernesto Schulz; Journal of Molecular Structure; vol. 1079; (2014); p. 9 – 14;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

To a solution of 2-(diphenylphosphino)benzaldehyde (0.279 g, 0.961 mmol) in CH2Cl2 (10 ml) in a Schlenk tube was added 2-methylaniline (0.103 g, 0.961 mmol) dropwise. Anhydrous magnesium sulfate (~ 0.5 g) was added to the Schlenk tube and the reaction was stirred at room temperature for 20 h. The resulting yellow mixture was filtered to obtain a yellow solution, which gave yellow oil upon evaporation of the solvent. Yield: 0.2990 g (82percent); IR (nujol cm? 1); nu(C=N imine) 1622, nu(C=C phenyl) 1593, 1585, 1505; nu(P?Ph) 1435; 1H NMR (200 MHz, CDCl3): delta 8.99 (d, 1H, J = 5.2, ?CH=N); 8.27, 6.91?7.67 (m, 12H, phenyl); 6.46 (t, 6H, J = 7.6, phenyl); 1.27 (s, 3H,CH3); 31P NMR (161.9 Hz, CDCl3) delta ? 13.96(s); Anal. Calcd for C26H22NP: C, 82.30; H, 5.84; N, 3.69; Found: C, 82.04; H, 5.93; N, 3.55., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Motswainyana, William M.; Onani, Martin O.; Madiehe, Abram M.; Saibu, Morounke; Thovhogi, Ntevheleni; Lalancette, Roger A.; Journal of Inorganic Biochemistry; vol. 129; (2013); p. 112 – 118;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The synthesis of the iminophosphine ligand carryingalkoxylsilane moiety (A) was performed through the reactivedistillation of 2-(diphenylphosphino)benzaldehyde (0.500 g)with 3-(aminopropyl)trimethoxysilane (0.255 g) in dry toluene(25 mL). After 5 hours, we obtained a yellow oily liquidby careful removal of toluene under vacuum (87 percent yield).1H NMR (400 MHz, CD2Cl2): delta = 8.8 (s, 1H), 8.02 (s,1H), 7.45-7.27 (m, 12 H), 6.91 (s, 1 H), 3.53 (s, 9 H), 3.46(m, 2 H), 1.68 – 1.60 (m, 2 H), 0.58 – 0.52 (m, 2 H); 13CNMR (100 MHz, CD2Cl2): delta= 158.57, 134.14, 128.79, 65.13,50.82, 24.62, 8.73 ppm.; 31P NMR : (300 MHz, CD2Cl2,ppm) delta= -13.07ppm., 50777-76-9

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Upadhyay, Praveenkumar R.; Srivastava, Vivek; Letters in Organic Chemistry; vol. 13; 5; (2016); p. 380 – 387;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To suspension of sodium dithiocarbamate 2a-f (0.5 mmol) inCH3OH (10 mL) was added a solution of K2PtCl4 (0.210 g,0.50 mmol) in H2O (10 mL). The reaction mixture wasstirred for 30 min. Next, a solution of dppf (0.28 g, 0.50 mmol)in CH2Cl2 (10 mL) was slowly added to the above mixtureand stirred for 24 h. KPF6 (0.46 g, 2.5 mmol) was addedand the mixture was stirred for another 8 h. The solvent wasthen evaporated, and dichloromethane was added to theresidue and the mixture washed with water. The organicphases were dried over anhydrous Na2SO4. The crude productwas purified by chromatography (eluent: CH2Cl2/CH3OH, 50:1, v/v) to give complexes 3a-f.3a: yellow solid, 0.30 g (Yield: 58%). 1H NMR (500MHz, CDCl3): delta 7.64 (m, 7H, -PhH), 7.56 (t, J = 6.8 Hz,5H, -PhH), 7.48 (t, J = 6.9 Hz, 8H, -PhH), 4.57 (s, 4H,-CpH), 4.38 (d, J = 1.7 Hz, 4H, -CpH), 3.54 (t, J = 7.2 Hz,4H, -NCH2-, -NCH2-), 1.20 (t, J = 7.2 Hz, 6H, -CH2CH3,-CH2CH3). 13C NMR (125 MHz, CDCl3): delta 133.94, 133.89,133.85, 132.29, 129.48, 128.99, 128.94, 128.90, 76.18,74.45, 44.67, 12.39. 31P NMR (200 MHz, CDCl3): delta 15.94,-144.30 (m). ESI-MS(+): m/z found 843.1473 [M-Fe-PF6]+,897.0880 [M-PF6]+, calcd for C39H38F6FeNP3PtS21042.0560.

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xu, Shou De; Wu, Xiang Hua; Journal of Chemical Research; vol. 43; 9-10; (2019); p. 437 – 442;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

General procedure: The stoichiometricamounts of [Cu(CH3CN)4](PF6)/Au(THT)Cl, K{S(O)COR} R = CH(CH3)2, CH2CH(CH3)2 and PPh3/dppf/PMe3 were taken in 100 mLround bottom flask containing 30 mL of acetone. The reaction mixturewas stirred at room temperature for 1 h under nitrogen atmosphere.The resultant solution was filtered and was evaporated todryness under vacuum to obtain a white solid. The residue was dissolvedin DCM and washed with water (3 20 mL). Finally theCH2Cl2 was evaporated to dryness under vacuum to yield complexesas fine white powders. The stoichiometry and the amountsof reagents used in each case are given below

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cyue, Jhih-Yu; Kishore, Pilli V.V.N.; Liao, Jian-Hong; Lin, Yan-Ru; Liu; Inorganica Chimica Acta; vol. 462; (2017); p. 97 – 105;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of phosphoresorcinarene 2a (0.06 mmol) in0.7 mL of dioxane was added hexamethyltriamidophosphite(0.590 mmol). The reaction mixture was heated for 60 h at 85-95C and then for 40 h at 110-115C. The precipitate was separated by fltration, washed with dioxane, and dried for 4 h at80C/1 mm Hg. White powder; yield 0.066 g (67%); m.p. >360C. 1H NMR (CDCl3, 25C): delta = 0.54 (s, 12H, C(CH3)2),0.75 (s, 12H, C(CH3)2), 2.15 (dd, 2JHH = 10.2 Hz, 3JPH =19.2 Hz, 4H, O-CH2e), 2.21 (s, 6H, C5CH3), 2.22 (s, 6H, C5CH3),2.50 (d, 3JPH = 9.2 Hz, 24H, NCH3), 2.62 (d, 3JPH = 8.4 Hz, 24H,NCH3), 3.24 (dd, 2JHH = 4.1 Hz, 3JPH = 2.3 Hz, 4H, O-CH2a),3.60 (dd, 2JHH = 11.9 Hz, 3JPH = 19.2 Hz, 4H, O-CH2e), 3.89(dd, 2JHH = 8.3 Hz, 3JPH = 2.7 Hz, 4H, O-CH2a), 5.14 (s, 2H,H3h), 6.16 (s, 2H, H3v), 6.33 (s, 4H, H1), 6.59 (d, 3JHH = 6.8 Hz,4H, H2-Naph), 6.74 (dd, 3JHH = 8.2 Hz, 3JHH = 7.3 Hz, 4H, H7-Naph), 6.89 (dd, 3JHH = 8.2 Hz, 3JHH = 6.8 Hz, 4H, H3-Naph),7.00 (dd, 3JHH = 8.2 Hz, 3JHH = 7.3 Hz, 4H, H6-Naph), 7.26 (d,3JHH = 8.2 Hz, 4H, H4-Naph), 7.35 (d, 3JHH = 8.2 Hz, 4H, H8-Naph), 7.38 (d, 3JHH = 8.2 Hz, 4H, H5-Naph). 13C NMR (CDCl3,25C): delta = 11.9 (C5CH3), 12.5 (C5CH3), 20.1 (C(CH3)2), 31.4(s, C(CH3)2), 31.5 (s, C(CH3)2), 36.8 (d, 2JPC = 3.7 Hz, NCH3),36.9 (d, 2JPC = 3.7 Hz, NCH3), 42.5 (C1), 77.5 (O-CH2), 122.6(C5), 123.7 (C5), 124.2 (C6,7,8-Naph), 124.9 (C3-Naph), 126.7(C4-Naph), 127.2 (C2-Naph), 128.2 (C5-Naph), 129.4 (C2), 130.4(C2), 131.5 (C3, C9-Naph), 131.7 (C3), 133.0 (C10-Naph), 137.5(C1-Naph), 147.2 (d, 2JPC = 9.6 Hz, C4OPO), 150.6 (d, 2JPC =7.7 Hz, C4OPN). 31P NMR (CDCl3, 25C): delta = 130.5 (4P),-14.0(4P). Anal. Calcd. for C108H136N8O20P8 (%): C 61.36, H 6.48, N5.38. Found (%): C 61.34, H 6.43, N 5.38.

1608-26-0, As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Glushko, Valentina V.; Serkova, Olga S.; Smoyan, Gavaz N.; Vasyanina, Larisa K.; Maslennikova, Vera I.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 192; 9; (2017); p. 1054 – 1060;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

Example 1 15.5 g of 2-chloroacetophenone, 31.3 g of 4′-n-pentoxybiphenyl-4-boronic acid, 7.5 g of sodium carbonate and a mixture of 44 mg of palladium as a 22% strength aqueous chloride solution, 1 ml of water and 720 mg of a 0.6M aqueous TPPTS solution together with 120 ml of ethylene glycol and 16 ml of water are placed under nitrogen in a reaction vessel and heated to boiling for 4 hours. After cooling to room temperature, 150 ml of water are added, the mixture is stirred vigorously for another 20 minutes and the solid which remains is filtered off. Crystallization of the residue from acetone and drying at 50 C. under reduced pressure gives 32 g (89%) of 2-(4′-n-pentoxy[1,1′]biphenyl-4-yl)-acetophenone having a melting point of 86 C.

As the paragraph descriping shows that 63995-70-0 is playing an increasingly important role.

Reference£º
Patent; Clariant GmbH; US2001/20104; (2001); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: Under N2 atmosphere, NaOAc (4.0 equiv), PPh3 1a (0.5 mmol), PdCl2 (10.0 mol %), AgOOCCF3 (5.0 equiv), CH3CN (2.0 mL) and methyl acrylate 2a (0.6 mmol) were successively added into a Schlenk reaction tube. Then the mixture was stirred at 60 C for 24 h. After cooling to room temperature, the solvent was evaporated in vacuo and then purified by flash column chromatography on silica gel to give the pure product 3a.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Ma, Ming-Tao; Lu, Jian-Mei; Tetrahedron; vol. 69; 9; (2013); p. 2102 – 2106;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

To a solution of 2-(diphenylphosphino)benzoic acid (375 mg, 1.23 mmol) in DMF (10 mL) in 0 C. DIPEA (0.4 mL, 2.234 mmol), Compound 1 (640 mg, 1.117 mmol) and HATU (640 mg, 1.675 mmol) was added. The reaction was continued by stirring at RT for 12 h and the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was diluted with water and stirred for 15 minutes. The precipitated solid was filtered off, washed with water and dried in vacuo. Purification of the crude product by column chromatography on silica gel (100-200 mesh) using methanol in DCM (0.5: 9.5) as eluent gave the detector according to the invention as a pale yellow solid (320 mg; 33.20%). Mito-1 was obtained., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Korea University Research Management System; Seon U-gyeong; Sang Ka-peu-rae-sa-deu-beu-heu-ni-ya; Kim Jong-seung; (17 pag.)KR2019/85401; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13689-19-5, Tricyclohexylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a sealed tube containing a solution of the phosphine oxide derivative (5 mmol) in anhydrous toluene (1 M) was added InBr3 (1 mol %, 0.05 mmol) and the TMDS (1.5 equiv, 7.5 mmol) under an argon atmosphere. The reaction mixture was stirred at 100 C during 7-40 h depending on the substrate (the reaction was monitored by 31P NMR). After complete consumption of the reagent the mixture was kept under argon in the sealed tube and cooled to 0 C. A solution of BH3.SMe2 (2 M in THF, 1 equiv) was then slowly added. After 1 h at room temperature, 31P NMR analysis of an aliquot indicates complete conversion to phosphine borane adduct. The crude was poured in an erlenmeyer flask and silica gel was carefully added while stirring. When silica gel was added in the reaction mixture, a slightly exothermic reaction was observed. The reaction mixture was then filtered on silica gel and washed several times with ethyl acetate. After evaporation of the ethyl acetate, the residue was purified by flash chromatography on silica gel with pure cyclohexane to afford the desired phosphine-borane.

13689-19-5, As the paragraph descriping shows that 13689-19-5 is playing an increasingly important role.

Reference£º
Article; Pehlivan, Leyla; Metay, Estelle; Delbrayelle, Dominique; Mignani, Gerard; Lemaire, Marc; Tetrahedron; vol. 68; 15; (2012); p. 3151 – 3155;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate