Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene. In a document type is Article, introducing its new discovery., 12150-46-8
Development of a scalable synthetic route towards a thrombin inhibitor, LB30057
Described is a scalable synthetic route towards LB30057 (1) which is based upon a chiron approach using methyl tyrosinate hydrochloride as a starting material. In situ protection of methyl tyrosinate to its N,O-bis-trimethylsilyl derivative and subsequent N-selective introduction of naphthalenesulfonyl group provided methyl N-2-naphthalenesulfonyltyrosinate (9). After the phenol group of 9 was Inflated to 10, nickel-catalyzed cyanation provided 11 in good yield. The acid chloride 11a was generated via hydrolysis of the ester group followed by the treatment with SOCl2, and then coupled with cyclopentylmethylamine to give the amide 15. Imidate formation followed by amidrazone generation and final salt formation with maleic acid afforded 1.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 12150-46-8, and how the biochemistry of the body works., 12150-46-8
Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate